One of UH Mānoa's major strengths is research. There are many research departments on- and off-campus. Below is a list of research units overseen by the Office of Research.
- Cancer Center
- Institute for Astronomy
- Harold L. Lyon Arboretum
- Pacific Biosciences Research Center
- School of Ocean & Earth Science & Technology
- Waikīkī Aquarium
- Water Resources Research Center